Protocol and appendices

The STAMPEDE protocol and its appendices have been amended. The most current version of the protocol and appendices are linked below – protocol v16.0 (dated 02-Mar-2017) and appendices v15.0 (dated 02-Mar-2017).

The protocol amendment is focused on the the addition of the "Transdermal Oestradiol Comparison" as a new research arm, open to all patients who have had a maximum of one 4 week (or 1 month) LHRH injection (with ≤ 8 weeks anti – androgens).   The current trial design is shown in the figure below: