Protocol and appendices


The STAMPEDE protocol and its appendices have been amended. The most current version of the protocol and appendices are linked below – protocol v15.0 (dated 29-Mar-2016) and appendices v14.0 (dated 29-Mar-2016).

The protocol amendment is focused on the the addition of the "metformin comparison" as a new research arm, open to all non-diabetic ment and reflects the accrual to the "enzlutamide+abiraterone comparison". Since the protocol was approved by HRA, accrural to the "M1|RT comparison" was completed on 02-Sept-2016. The current trial design is shown in the figure below:

                                                  Protocol_15_Arm_K_trial_schema