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Home Page > Centres > Information for centres > Eligibility Criteria

Main entry criteria:

[1]  Newly diagnosed high risk N0 M0 patients with:

·  At least 2 of: Stage T3/4, PSA ≥ 40ng/ml or Gleason sum   score 8-10    

And intention to treat with radical radiotherapy

[2] Newly diagnosed M+ or N+ · Stage T_any N+ M0 or T_any N_any M+  with histological confirmation

or [3] Previously treated with radical surgery or radiotherapy, now relapsing

· PSA  ≥4ng/ml with doubling time less than 6 months

· PSA ≥ 20ng/ml

· New metastatic or nodal disease

 

  For all patients

· Histologically confirmed prostate adenocarcinoma

· Intention to treat with long-term hormone therapy

· Fit for all protocol treatment and follow-up, WHO performance status 0-2

· Have completed the appropriate investigations prior to randomisation

· Adequate haematological function: neutrophil count >1.5x10⁹/l and platelets >100x10⁹/l

· Estimated creatinine clearance >30ml/min

· Serum potassium ≥3.5mmol/L

· Written informed consent

· Willing and expected to comply with follow-up schedule

· Using effective contraceptive method if applicable